Anyone with insight into the industry know how much institutional knowledge would be relevant still with an ISA switch?
I reckon 5 years from now it'll be obvious that x86 is on its way out, and 10 years from now it'll be replaced by ARM in all but narrow backwards compatibility demanded use cases.
I also predict that the survival of both Intel and ARM as big players in the market is contingent on them switching in the same timeframe. If they don't, they're dead (of course, if they try to switch and botch it, they're dead too - but baking that into a prediction feels a bit no-true-scotsman esque).
I'm hopeful that manufacturers will ship regular socketable ARM cpus just like they do with x86 now, but who knows whether that will be the case or if we'll move more towards everything being soldered on all in one solutions.
so now mobile, desktop and server all looking good with ARM? i can't see why it would go backwards at all.
Also beware of what you wish for, that is basically the end of PCs when it comes to be, the dream of OEMs, going back to fully vertical integration as all computers used to be in the last century, with exception of PC clones, thanks to IBM failing to control the ecosystem.
It didn't, other than in some niches.