Add coffee shops and restaurants nearby, help promote casual entertainment venues like mini golf, community theatre, and weekend markets.
Grow from there based on the type of demand that appears, keep business rates low for the area.
They say it can't be done, but when that last shop closes right now there will be no choice.
To combat the dereliction and anti social behaviour they would have to rebuild anyway, and it will cost them more later than gradual repurpose/ investment.