For me, 'restart' is generally the most used operation during debug. The vast majority of the time I want to rerun through the init code to clear out the registers and any previous transactions. If I've set something up incorrectly, I can always set a breakpoint and adjust.

So I'm not seeing an immediate benefit to direct modification for my normal workflow. There may be good use cases when writing code that isn't HW dependent or if the compile/flash cycle takes a long time, but those aren't problems I've had very often over the last ~10 years.