This is also risky because it could leave the file in an inconsistent, partially-modified state. However, in practice it seems to work really well, and Google turns up a striking lack of articles discussing the risks of inconsistency due to use of mmap.
I'd like to learn more about the risks of this approach, since I'm using it to selectively rewrite portions of a very important file in a project of mine. I'm pretty sure that my usage pattern is safe. The writes are small enough that they nearly always affect only one disk block and never touch more than two, and I'm careful to msync() at the right places (actually mmap.mmap.flush(), since I'm using Python), but I'm interested in learning about potential issues. This file is too large to make copying it convenient, but I'll do that if necessary.