I met some Counsyl devs at PyCon last year, they were wonderful. We talked about meaningful work.
There are so many companies and nonprofits trying to change the world. They need help with software. A partial list:
Broad Institute: http://www.broadinstitute.org (disclaimer, I work there)
JCVI: http://www.jcvi.org
Sanger: http://www.sanger.ac.uk
23andme: https://www.23andme.com