Django is a pretty decent web framework for Python (Python being a language that's loved very much by a large majority of folks here).

Pinterest, Disqus, Instagram, PBS site, Washington Post site, etc. etc. are all Django projects. It's definitely worth learning -- the community is helpful and in large numbers, the framework is quite 'complete' -- there are lots of plugins available, it's fairly secure... and it's a pleasure to work with. :)