He's talking from experience. Between the late 1990's and early 2000's, the Bill & Melinda Gates Foundation wasted around $1.7 billion on a broad-ranging, intensive, national effort to study small schools... based on a flawed measurement of Bayesian probabilities!
The foundation looked only at the probability that a school would be small given high school performance, and seemingly forgot to look at the probability that a school would be high-performing given a small school size. The two are not the same. $1.7 billion, poof!
The following analysis, by a professor of statistics, explains in more detail how the foundation got it wrong: http://press.princeton.edu/chapters/s8863.pdf