I've also successfully implemented Zakas' [1] approach after watching his presentation "Scalable Javascript Application Architecture" [2] and abandoning Backbone.Aura [3]. Aura theoretically implements this, but in practice we found that it made some assumptions that were incompatible with our needs. Consequently, we rolled our own implementation.

[1] http://www.nczonline.net/blog/about/

[2] http://www.youtube.com/watch?v=vXjVFPosQHw

[3] https://github.com/aurajs/aura

This video:

http://www.youtube.com/watch?v=vXjVFPosQHw

(which was also posted by politician) was very useful in explaining the theory. I also made some changes to it, but offhand I can't remember what they were. I think it was to do with the separation of starting vs initialising modules (parts of a page).