Totally. We played Assassin with platic-disc guns (which I can't find on Amazon) in high school. The school came down on us pretty hard if we were caught playing, so it was doubly stressful avoiding getting whacked by friends and avoiding being caught by faculty. We also had an entrance fee of $5, so the winner took home $100-$200 for surviving.

I never survived.

In general, though, the idea of adding a little game to anything is pretty nice. You can imagine playing tag at CES or assassin at PyCon. Hell, it's be great if the organizers added/encouraged/managed it!