Indica vs Sativa.
I have severe doubts that that makes as much difference as... well anything.
It's like whisky drunk vs. beer drunk, they're different because of the speed you take them in, their concentration absorption speeds and a variety of subjective feelings.
Now I know it's a little more complicated than the ethanol picture, with a variety of active compounds in different quantities, but I am very skeptical that a different strain of the plant can make the change from 'stumbling through life apathetically' to 'deep psychedelic self-realisation'.
Not that I'm convinced deep psychedelic self-realisation is much other than brainfart either.
All I was really trying to point out was that there are clearly different 'states' of high: introspective (to the point of paranoia), inquisitive, giggly, zoned, etc.
Just as there are different states of drunk: 'tipsy', 'hyper-active', 'depressed', 'blotto', etc.
So just as not everyone who hits a beer bong is going to streak across the quad to the gymnasium, not everyone who gets high is going to necessarily question the universe nor necessarily sit on the couch and watch the world pass by.
You can't gauge marijuana from the actions of a handful of stoners any more than you can gauge alcohol from the actions of a handful of stumbling drunks.
And it's all besides the point anyway. Giving somebody who rarely smokes, or never has smoked, a bowl of hardcore sativa is a really, really stupid idea unless you want to babysit them all night.
It's also weird to pretend that one class of herbal is radically different from another. There are differences, but they get exaggerated.