Create a website/portfolio. If you can show 4 years of work/projects that will do you better than 4 years of school. I see you've got a github, that's good, expand on it. You don't need big projects, small ones work as well. Comment and format your code well. This is what people will see.

Look at what skills people in your area need. There are zero python jobs in my area. I love python, but it isn't marketable. It's either PHP or C#/.Net. So for my current job I did some C# projects while unemployed to show with my resume.

Your first job will probably suck. This is true of a lot of college grads as well. Don't be discouraged.