Honestly, having a professional tell me that I was depressed was the turning point in my life. Suddenly the big problem in my life wasn't that I was such a loser, it was that I was inclined to think that I was such a loser. And this new problem was one that I could manage: finding new triggers to my depression and avoiding them; understanding when I'm being unreasonably demanding of myself or others because I've entered an episode; knowing how to help break the negative thought loops that sustain an episode of depression.

If you ask how to start a successful business, then I will give you advice on that. If you ask how to stop being a loser, then I will suggest that you are not a loser and you have some depression. In that case, what helped me was getting a diagnosis, reading books on psychological disorders, understanding CBT, and mindfulness meditation/vipassana.

And if you are both depressed and wanting to start a successful business, I suggest that the best place to start is in learning how to deal with your illness.