What pain points does pythonbrew solve? Im curious as the linked blog post was a bit light on detail
If you are from ruby / rails world, you will love and be at home with pythonbrew.
Because of that, I've gone back to using homebrew to compile multiple versions of python and letting tox utilize those. Homebrew takes care of pip & distribute so adding virtualenv & virtualenvwrapper is a simple oneliner after the fact.