>> Horrible to refactor. I mean really horrible. You don't get everything right the first time and when it comes to fixing that it's hell
I think dynamic languages like Python and Ruby are an absolute joy to refactor. There is generally less code-junk to be worrying about when making refactorings. I realise this is subjective however, I think it's difficult to make a serious case that any one language is easier to refactor than another. Granted, the refactoring tools in IDEs for Ruby/Python etc. are much more limited than say C#.
I hope you won't mind if I don't get into the indentation or type safety arguments. They've been done to death! :)
I think we're in agreement that if you need something to be really fast you should use a different language. I just don't think that's a reason to not use Python for the rest of your app. And of course as others have pointed out the vast majority of us are not writing apps that require super fast algorithms, we're all far too busy doing the same CRUD stuff over and over right :)
I appreciate your insight on a 100kloc Python project though, I have to admit I've not encountered anything of that size. At work we have a much smaller codebase that has already gotten out-of-hand but I believe that's entirely due to the developer responsible, not the language.