The whole setup seems a lot simpler than nearly every 'web scale' solution I've heard discussed.
EDIT: I'm not saying that is a bad thing - it's a good thing. Most of the articles around scaling on HN often deal with very complex Cassandra style technical solutions. This article is the opposite with a very 'just do it the simplest way' feel to it. One big mysql table for all users (probably with some memcache in front) is the sort of thing you can put together in an hour or two - yet it is the very core of their system.
I (and I bet a lot of other engineers reading HN) try to focus too much on perfect implementations - if someone asked me to design the shard look-up for something as heavily hit as this, I'd probably reach for a distributed in-memory DB with broadcasted updates - and I'd probably be wrong to do so. The mysql/memcache approach is just going to be simpler to keep running.