Imagine if Einstein thought something (let's say for the sake of argument that he had access to some real close-to-speed-of-light experiments): "classical mechanics, isn't wrong, but predictions for close-to-the-speed-of-light experiments don't match the reality because we live in a simulation and the resource constraints forced by the computations needed for the simulation computer to do for such cases make it distort things through heuristic approximations ...and because we live in a simulation I can further pursue my other line of work, the genetic theory of Leprechauns and Fairies...".
Now I actually believe the plausability of the simulation theory, unfalsifiable as it may be, and all, but I think such simulations wouldn't be run for "fun" alone: if we're in a simulation, we're either (a) "babies" in nursery that probably involve multiple existences in multiple simulations until we are "prepared" for the "top-level reality" or (b) we and our universes are a very advanced form of... future "bitcoin miners" :| (I sincerely hope for either (a) or the plain ol "reality is real" theory, but one can never now...)