No. Use homebrew for system packages and use pip to install python packages. It's much more flexible and doesn't rely on package managers keeping up with releases.

In the real world, a typical pip requirements.txt file will have a mix of package names (which pip looks for and downloads from an index like pypi), git repo urls (eggs installed directly from a git server, eg from github) and bleeding edge track the latest changes -e git-repo#egg=eggname urls. That you can switch between these with ease is important, eg to switch to using your fork of some package rather than the last official release.