I mean, if it was legitimately life-changing money, I could take the buyout, spend a year or two traveling, relaxing, exploring, enjoying the "good life" and looking for a six foot tall redheaded supermodel with a Scottish accent to be my girlfriend... and then, when I got bored with that, I'd have seed money for the next venture already in hand.
OTOH, how do you see your baby? When you pour blood, sweat and tears into something to that point that it's basically your life, how can you just walk away from that with some cash?
So I dunno... which is why I say I think I'd take the buyout, but I can't necessarily swear to it.