From experience, if you stick with standard UIKIt navigation schemes (i.e. use nav bars not FB/Twitter style pop-unders) and, critically, standard Apple approved color schemes (i.e., light not dark UI elements) then crafting an app within Storyboard is incredibly straightforward, especially if you consider PaaS solutions like Parse.com integration[1]. The problem seems to be managing the complexities of non-standard UI elements.
For what it's worth, Jony Ive seems to be pushing us to all adopt the design approach of the OP. Wonder if 'deference to content' will become the new normal?
[1] http://blog.fieldforceapp.com/post/32922733018/weekend-proje...