I hope there is a way to disable auto-rotation for reading in bed. That is a big pet peeve with my iphone.
The screen changes automatically when you rotate your Kindle from portrait to landscape or vice versa. Or, you can lock your screen to a particular orientation to fit your reading position.
However, since this is a much bigger device, I am not sure if reading in bed is going to work the same way it does for the iPhone.
Every orientation you could want, even left-handed!