What we're left with are the ones that only work in a mild, sometimes-sort of way. And don't buy the notion that the purpose of an antidepressant is to "correct chemical imbalances." No such imbalances have ever been identified:
http://www.etfrc.com/ChemicalImbalances.htm
"How are the chemical imbalances which are the supposed basis for the prescription of "antidepressants" diagnosed? Is exploratory neurosurgery performed, using some technique that allows the surgeon to quantify synaptic transmitter levels? No, the very idea is absurd. Is a spinal tap, then, done to at least measure, on a gross scale, the distribution of neurotransmitter metabolites? Of course not – how many people have undergone spinal taps before receiving a prescription for Effexor®? Is blood at least drawn, to test something? No. This diagnosis – the diagnosis of the most subtle of chemical disorders in the most complex organ in the body – is made on the basis of the patient's report of feeling sad and lethargic. Try to imagine a hematologist diagnosing leukemia this way to get a sense of just how ridiculous this idea is."
"The principal reason for rejecting biopsychiatry (aside from the fact that intellectual honesty demands its rejection) is that it locates the cause of psychic suffering in people's "bad brains," and excludes the conditions of modern life, or anything else, from consideration as the cause of such pain."
The purpose of an antidepressant is to improve mood. No more, no less. And the degree of doublespeak doctors find necessary to dance around our society's puritanical views on pleasure just to be permitted to market the current, wimpy antidepressants - is staggering.