To design responsive web applications, you need to see the (browser) windows content on re-size. This is not default in Ubuntu/Unity, you cannot see a windows contents when you are resizing. You can enable it, but its slow and not very useful. The content in a window needs to re-flow fluidly and quickly, especially the browser.
Its as simple as that for me. Until Ubuntu has hardware accelerated window re-sizing, i simply cannot use it as a development platform. Responsive Webdesign isn't going anywhere anytime soon, and responsive apps/websites are a chore to effectively debug on Ubuntu compared to other OS's