The Mathematics of the Manhattan Project
math-blog.com
math-blog.com
FMEA and safety related strands are a major component of modern day similarly sized projects. Even to the point of preventing them from ever being completed.
An apt metaphor might be the automobile. If it were invented, afresh, today would it be even remotely similar? And what is the ratio of the cost of developing the first viable automobiles compared to the cost of today's relatively minor iterations, per functional unit delivered? Miniscule I imagine.