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Sure. I have a scanner that is now useless because Canon never released a 64-bit driver. (The useful lifetime of a scanner is longer than the life of an individual PC or the time a manufacturer will support it.) Lots of scientific and industrial equipment will not have 64-bit drivers.

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You could use it in a 32-bit VM. Since I went 64-bit, I've been using my Lide20 CanonScan though a 32-bit XP install in VirtualBox. Sure, the VM takes 20 seconds to boot to desktop, but that's better than junking a working piece of hardware simply because the manufacturer doesn't support it.

Try using VueScan. It supports a bunch of older scanners.

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