The fact that there are mysteries that no life will ever have answers to is quite humbling.
If you find physics interesting, then you'll love these Feynman lectures. Feynman is so good at explaining these concepts that you don't even need any formal training to understand them.
Lecture 1: The Law of Gravitation http://www.youtube.com/watch?v=j3mhkYbznBk&list=PL8976CAAD2A...
Lecture 2: The Relation of Mathematics to Physics http://www.youtube.com/watch?v=kd0xTfdt6qw&list=UUR3AOHJ5xJv...
Lecture 3: The Great Conservation Principles http://www.youtube.com/watch?v=r_IfV9fkBhk&list=UUR3AOHJ5xJv...
Lecture 4: Symmetry in Physical Law http://www.youtube.com/watch?v=zQ6o1cDxV7o&list=UUR3AOHJ5xJv...
Lecture 5: The Distinction of Past and Future http://www.youtube.com/watch?v=zQ6o1cDxV7o&list=UUR3AOHJ5xJv...
Lecture 6: Probability and Uncertainty http://www.youtube.com/watch?v=Ja0HSFj8Imc