> I like prose that is a commentary on observations about life, man and business, if you're able to find anything.

No idea about prose, but in terms of fiction, Death of a Salesman is the obvious one, I guess. Also, Rise of Silas Lapham, maybe?

I'll be honest with you, I don't like to read books about man and life and business all in a single work. I took a few American literature courses, but none dealt with all those themes.

For something completely different, have you ever read Slaughterhouse-Five?