My problems are mostly how easy it is to get lost if you're dealing with nested tables within tables (especially inside templates), and that they have to be completely read before rendering... although that may no longer necessarily be an issue with modern browsers.
I find divs and spans easier myself but I guess, yeah, at the end of the day if it looks fine and it loads fine then it's fine. Too much pain from hand-coding too many tables has made me twitchy and curmudgeonly.
Oh, and don't view-source on HN ;)
Oh, i'm aware...
It's just too bad html doesn't provide elements that handle nested lists. If only. Ah well.