I'd agree, that one phrase seems a little out of touch. If it had been phrased differently (e.g. "Do something that changes the world") I still would have taken issue with it. I'm not attacking the phrasing so much as the sentiment that startups need to have Google-level ambitions (something I don't think Larry and Sergey had in the beginning, in fact). Even pg has observed in one of his essays that not all founders set out to disrupt entire industries.

But to be fair, there are plenty of examples of companies (Microsoft, Google, Airbnb, Dropbox) which arguable have legitimately augmented the human condition for huge numbers of people. There's just plenty more that didn't, and that's okay.