Can we get a real UI, autoupdates (and without needing to download the whole giant binary every time), a database that doesn't choke on realistically large libraries? How shaving some time off of the 45 seconds the application takes make an Amazon API call to grab metadata and a tiny cover image? These are just the obvious, major issues that have been present for years now.
Calibre is already that half-assed community project cliche. One that has so much potential at first, but falls apart since no one can see the forest among the trees. Has been for a while now.