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If you're going to write it in C, why not just write it in Java? You could use the Google Web Toolkit..

removed ... i'm embarrassed at the wrongness of what i typed

Kind of. Similar syntax and design patterns, but I don't think you can directly compile a Cocoa application to Cappucino, or vice versa.

Rather, write in python, profile it, and replace all CPU-intensive functions by C code in a custom python module. Best of both worlds.

Or write it in Python, then run it under Jython.