See: Belltown in Seattle. Originally an artist neighborhood (as gentrifying neighborhoods tend to be), now completely devoid of art. Originally featured eclectic eateries and cafes, which attracted wealthier residents who liked the bohemian feel. Nowadays it's high-end chains and a lot of ostentatious lounges/clubs.
It's gotten to the point where Belltown is no longer really a desirable place to live, and the interest is now in Capitol Hill, where there is still an artistic/bohemian scene.
Change isn't bad, but in this case the pattern seems to be: residents move in attracted to X, driving X out in the process, everyone wonders where X went, and this starts the migration to another neighborhood in the search of X... Repeat ad infinitum.