Doesn't seem to be doing much damage to Mac software houses/indies...
>According to [1] (published about half a year ago), the Mac OS X market share breakdown: Mountain Lion 10.8 26.8% Lion 10.7 28% Snow Leopard 10.6 35.1% Leopard and lower 10%
So just target Lion and above, that's 54%, which might sound small, but it's tens of millions of users. Mac software houses thrived in 2005 with 1/4 the user base that what that 54% represents.
That said, I highly doubt SL is 35% still.