Have you used the HTC One?
One example is with the hardware buttons. They are so flush against the body (both the sleep/wake and volume), that you almost always have to look to see what you're doing. I can't blindly turn down or up the volume nor can I wake up the phone in my pocket before I take it out like I do on my iPhone.
EDIT: I was referring to the Nexus tablet that came out not long ago (though we do have a Nexus 7 at the company also)
Of course the rest of the problems are OS-related (even vanilla).