Grandfather was in decent shape at 40 when pretty much all his arteries clogged. He is now 87 with half a single artery left in his heart. He is not what I would call "living" as much as existing.
On the other side, my mother, grandmother, and great grandmother have intense high blood pressure with no understandable reason.
Well, I figure I may have till I'm 50. Though I hope doing biking marathons would train my heart even a bit to help.