You might think that, if you've worked with IE10, it's going to be smooth sailing. It's not. IE11 is a regression in comparison.
The browser quirks aren't things like "Oh, you need a vendor prefix here." They are things like, "no matter what, keyframe animations will never work at all in the presence of the Facebook API, and transition animations will work sometimes (but not always!) because reasons, and sometimes (but not always!) animated elements will reset back to their original position after the animation completes."
Because of these browser-specific quirks, you'll be spending a fair amount of time in the IE11 developer tools, which are very nearly unchanged since interns wrote them in IE7. Worse, they frequently crash and take the browser down with it. Or, they get out of sync with the browser, and "Inspect Element" stops working until you restart the browser. You'll be restarting IE and staring at the "Searching for solutions..." dialog quite a bit.
When the tools DO work, you'll find they've added a bunch of new stuff like the "UI Responsiveness Wizard", but that's a poor consolation prize for losing the great debugging features of other browsers, like "Break on attribute modification" and "stabililty."
And, after spending days poring through JS, trying to find any sort of IE11-specific bug or behavior on these complex sites that work in very nearly every other browser, including IE10 and an array of mobile browsers going back to Android 2, you'll find that adding random timeouts will start fixing some of these weird behaviors.
I've been mired in IE11 support for the past several months. It's been a nightmare.
So yeah, they fixed that, then once I started using the tools, I suddenly realized they completely stripped out the Document Mode/Browser Mode so now you have to figure out some other way of testing old versions.
Oh, but wait! Browser Mode is now back in, not in an update mind you, but only available in Windows 8.1. Seriously, WTF!?
You can see the differences in the UI here: http://net.tutsplus.com/articles/the-new-ie11-f12-tools/
The parts that are most important to my work have largely gone unchanged, and the debugging tools I use most from Chrome and Firebug are nowhere to be found.
You can reach me at stevebe@microsoft.com.