I put my browser cache, several logging files and other volatile things there. Whenever I download something just to dispose it later, it goes in there. If I try something stupid with a lot files or some big ones, it goes in there.
It feels much nicer than to fragment the harddisk for such things; maybe it is just a placebo but it makes me happy. And of course access and usage of those files is blazing fast.
PS: Having Opera's temporary download directory automatically wiped away alone is worth it... :)