The main considerations will be:
- Set routes/paths the drones must follow, taking I to account altitudes that minimise traffic with other things high up (buildings, aircraft, UFOs) - emergency procedures and a risk assessment for each foreseeable eventuality (not that hard considering the lack of other traffic 'up there') - limits on the amount of drones in the air within constrained geographic localities.
It is likely that this could all be agreed for a single trial city well before 2015 rolls around. This isn't rocket science...