I've seen plenty of software (especially systems software) that does spend much of it's time in tight inner loops. Pulling out all the optimization stops there can give measurable gains. I've personally seen measurable gains on real applications from tricks like reordering branches so that the more predictable branches go first.
So it's situational, but IME it's pretty predictable where you'll see this kind of optimization help. By all means profile and use whatever tools at hand to help you along, and don't apply the optimization blindly - but despite the whole "black art" label optimization sometimes gets this kind of thing really is pretty straightforward.
The danger is that benchmarks like this encourage naïve programmers to use complex constructs as a matter of course, when simpler would usually be better. "Premature optimisation is the root of all evil" and all that...
Are there any open source projects amongst your examples?