As a trivial example, there's a Taco Bell located literally about 300 feet from where I'm staying, but getting there on foot requires a detour of about a mile because it, like all other business establishments on El Camino Real (substitute your suburban highway of choice), is surrounded by concrete wall on all three sides except the one facing the highway. Which means the foolish pedestrian needs to walk around the entire block to get there.
Another trivial example of pedestrian-hostility: the city of Mountain View, being run by nice, eco-friendly hippies sucking on the Google bong, has banned plastic bags in supermarkets, mandating the use of paper bags instead. However, this also has the side effect of making it virtually impossible to complete your shopping by any means other than car, since paper bags disintegrate if you look at them sideways or attempt to carry them more than the distance from checkout to parking lot, much less (say) stuff them in your backpack, hang them from the handlebars of your bike, or even swing them a bit while waiting at the traffic lights.