Thats a huge drop. How accurate is Quantcast?
Here is some drastic example I found recently (thin/spammy content penalty I guess):
http://extremetracking.com/free?login=fm3u91 http://www.alexa.com/siteinfo/freemp3us.com
From 14,000,000 uniques a month down to ~80 a day :D But obviously Google still has work to do, since that site made a lot of money within that 1-2 months period.