Email providers should (optionally) bounce spam, rather than sending it to a spam folder. This would eliminate the problem of false-positives, since senders would be notified. It would reduce traffic, since spammers would know the message didn't get through to any inbox, and so would focus elsewhere. Finally, it would eliminate the temptation of a spam folder for people who don't want spam, but peek 'just to make sure', and thereafter go on to support spammers.
Perhaps someone here is running an email provider, or working on such software?