Funny, after years of Win32 C++, VB, and then web development, I find I can slap together an interface so much faster and better-looking using HTML/CSS/JS than anything for the desktop.
However, "slap together" may be the important phrase -- putting together a well-architected, consistent, extendable, etc. interface is perhaps a little hairier. But the DOM is great for building UI's quickly, with trivially easy custom styling and graceful resizing.