Right now the python plugin works by running a little tcp client and connecting to LT's main tcp server. You'd just need to flip those. The Clojure nREPL stuff does this, though it might be a hair bit more complicated than what you'll need for the python one: https://github.com/LightTable/Clojure/blob/master/src/lt/plu...

Past that, you'd just need to add something to the python plugin that runs a tcp server in your process and then hooks into the python running code that's already there. https://github.com/LightTable/Python/blob/master/py-src/ltma...