They can make it impossible given the device is not jailbroken. Sometimes there are versions of iOS that are un-jailbreakable. If you are not Apple, it could very well be impossible to figure out what an app is sending to a remote service if it gets its cryptography right.

Edit: thinking about it, although it may be impossible to MITM the connection, presumably one can inspect the compiled application to determine what it would send, so I think I was wrong about this