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I guess you could classify it as selfish under some weird definition that classifies everything dangerous as selfish

No, under the definition of having loved ones who will be terribly upset in case you die or irrepairably injure yourself.

I think it is rational to classify certain voluntary highly dangerous activities as selfish if others will suffer in case an accident happens to you.

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Working countless hours on your startup project can also have devastating effects on your loved ones. They may be terribly upset. Your selfishness may be altering their future, and not for the better. (Using "you" in a generic sense here).

This doesn't negate his point.

Only proves that working on a startup can be selfish too.

loved ones (naturally) being upset doesnt mean they havent been considered, or that they would want to prevent you from doing something you wanted just because of the possibility it results in a situation of them being upset.

By that definition all dangerous activities are selfish, I dont think thats useful.

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