Some big companies do use, others do not.
The reason for the variability is that it's neither the be-all-end-all framework not a de-facto standard, so no reason to prefer it over another good framework like Ember or Knockout etc.
Besides most companies already have codebases in other frameworks.
We are doing a rewrite of our frontend and evaluated Ember, Backbone, and Angular. Our frontend devs liked Angular best so we went with it. We're about 8 months into the rewrite and it's gone very well so far.
Shameless plug: we're also hiring Ruby and Javascript devs local to SF as well as remote. My email is in my profile.
I work on a large e-commerce site, we are moving towards Angular where it makes sense but projects that allow us to scrap existing code and start over are few and far between.
Google uses Angular for a few projects.
Amazon AWS uses Angular for their dashboard.