On the specific issue of body weight, "normal" weight ranges for a given height were defined years ago on the basis of statistics on weight distributions in the general population. Oddly, current mortality and morbidity statistics tend to show that the persons with longest expected lifespans are not persons with "normal" weight as defined by body mass index but rather persons who are (slightly) "overweight." (This is however, most true for "overweight" persons who have good cardiovascular fitness.[2]) So if today's population in developed countries weighs more than populations a generation ago, the issue to look at is how many people have shifted from underweight to normal weight, how many from normal weight to overweight, and how many from overweight to obsesity. Obesity is definitely harmful to health. Moderate physical exercise, the kind I get by substituting walking or bicycling to do errands for driving, is surely good for pretty nearly everyone, independent of other lifestyle factors. But it has yet to be shown that antibiotic intake in the current amounts experienced by human beings in the developed world is harmful. There has been investigation in the last decade or so of the hypothesis that some antiobiotics may be protective against heart disease,[3] for instance, although maybe not all antibiotics have the same risk-benefit profile.
[1] http://www.nature.com/scientificamerican/journal/v307/n3/box...
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