Summary: It’s plausible that a fuselage section near the SATCOM antenna adapter failed, disabling satellite based - GPS, ACARS, and ADS-B/C - communications, and leading to a slow decompression that left all occupants unconscious. If such decompression left the aircraft intact, then the autopilot would have flown the planned route or otherwise maintained its heading/altitude until fuel exhaustion.
May be I am wrong, but If the gps failed, how can the autopilot work?