I've also greatly enjoyed reading the compiler/VM backstory on http://wingolog.org/ . It occurs to me that if you have an efficient Scheme VM, you could use it as a target for a lot of other languages and get something of an 100% OSS .Net or Java polyglot ecosystem going. Parrot was the previous hope but it seems to have fallen into being a mostly academic exercise.
And then there's "GuileMacs", which seems to get closer to a reality with every push. Not being a native Lisper, I think Emacs could use a boost from having a faster VM and lexical scope.
Really there's just a lot to love about Guile. I'm excited about all the activity and attention it's getting.