It would be nice to see other languages available as real languages, not compiled down to Javascript. I love me some javascript, but it would be nice to work in Python, in the browser.
What we have now isn't the very best thing I can imagine, but I think it's an OK compromise. We have a set of runtimes that implement a fairly consistent Turing-complete set of instructions, so we can implement just about anything we want and express it almost any way we want. And in the end, I think that's the most important thing.
Things like ASM.js are interesting, but not really helpful, in my mind, as it just adds another unnecessary layer of overhead just to be able to implement something interesting in a language suited to it. I just wish browser vendors saw this the way I do.